Thanks all. The Preen2 really fits into the way I work now, whether playing live (at home live, not out and about live) or making tracks. I devote four midi channels on my Digitakt to sequencing it, and On the first channel I set up the CC to manage combo changes. On my live templates I set up a combo per 'pattern' and set the macro knobs on the Digitakt to control the performance knobs on the Preen so I can parameter lock them if I want to.
I've also recently added an Elektron Analog Keys to my setup so I can run the Preen through it, giving me a Chorus, Reverb and Delay as well as a nice aftertouch keyboard. When I was routing it through my Digitakt I was limited to receiving only a mono channel in my DAW over Overbridge. Now with a little setup I can receive my 4 mono tracks from the Analog Keys as separate outs to my DAW without effects, and I can have the master out devoted only to a stereo signal of the Preen effected by the Keys' effect and filters.